Roman Hillje

Data Visualization & Bioinformatics

Activity

PhD student in Computational Biology / Molecular Medicine at the Department of Experimental Oncology, European Institute of Oncology (IEO - Istituto Europeo di Oncologia) in Milan, Italy.

Skills

  • Bioinformatics, programming and data processing in R and Python.
  • Working with job scheduling systems such as SGE and PBS.
  • Container-based, automated workflows with Snakemake, Docker and Singularity.
  • Interactive apps for data visualization with Shiny.
  • Deploy standalone Shiny applications with Electron.

Previous Research Projects

  • “Automation of an in vitro selection process”, Master Thesis @ Leibniz University, Hannover (DE)
  • “Evaluation of the cancer-preventive effect of Resveratrol-loaded nanoparticles on the formation of tumor spheroids”, Research Internship @ University of Rhode Island, RI (USA)
  • “Engineering a synthetic microbial consortium”, iGEM competition @ Team TU Braunschweig, Braunschweig (DE)
  • “Regulated Cytidine Deaminase Expression by Improved Doxycycline Inducible Lentiviral Vectors in Human Hematopoiesis”, Bachelor Thesis @ Hannover Medical School, Hannover (DE)

Other Activities

Education

  • 2014: M.Sc. in Biotechnology - Biochemical Engineering, Technische Universit├Ąt Braunschweig (DE)
  • 2012: B.Sc. in Biotechnology - Applied Cell Biology, Technische Universit├Ąt Braunschweig (DE)

Publications

  • [preprint] XenoCell: classification of cellular barcodes in single cell experiments from xenograft samples. S Cheloni, R Hillje, et al., bioRxiv (2019). Link
  • Cerebro: Interactive visualization of scRNA-seq data. R Hillje, et al., Bioinformatics (2019). Link
  • Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology. S Amatori, G Persico et al., Clin Epigenetic (2018). Link
  • iPSC-derived macrophages effectively treat pulmonary alveolar proteinosis in Csf2rb-deficient mice. A Mucci et al, Stem Cell Reports (2018). Link
  • Tightly regulated ‘all-in'one’ lentiviral vector for protection of human hematopoietic cells from anticancer chemotherapy. N Lachmann, S Brennig et al, Gene Therapy (2015). Link